What do systematic reviews say?

2 questions · 4 findings · 1 reviews · Oral Health

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No studies found 0 · 0%GRADE not reported 1 · 25%Very low 1 · 25%Low 0 · 0%Moderate 2 · 50%High 0 · 0%

Fluoride agent (e.g., NaF/SDF/KF/CaF2) vs No biomimetic remineralization (control)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

In the Etch-and-Rinse adhesive + biological ACAD protocol network, Fluorine showed 4.197 MPa higher 24 h bond strength than Control (MD 4.197, 95% CI 1.080 to 7.314; Moderate certainty).

3 findings from 1 review

Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. 2025 All outcomes
24 h (immediate) · In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS) · Etch-and-Rinse + biological ACAD
MD 4.197 [1.080, 7.314]
4 studies
Moderate
Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. 2025 All outcomes
24 h (immediate) · In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS) · Etch-and-Rinse + chemical ACAD
MD -0.120 [-3.783, 3.544]
8 studies
Very low
Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. 2025 All outcomes
24 h (immediate) · In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS) · Self-Etch + chemical ACAD
MD -0.601 [-2.932, 1.730]
8 studies
Moderate

Silver diamine fluoride (SDF) vs No biomimetic remineralization (control)

Immediate (24 h) resin-dentin bond strength (MPa) · Artificial caries-affected dentin (ACAD) in extracted permanent human teeth (in vitro)

Only one in vitro study assessed a Self-Etch adhesive with the biological ACAD protocol; it was insufficient for network meta-analysis, so no pooled effect estimate is available (ungraded).

1 finding from 1 review

Biomimetic Remineralization Strategies for Dentin Bond Stability-Systematic Review and Network Meta-Analysis. 2025 All outcomes
24 h (immediate) · In vitro; extracted permanent human teeth; bond strength testing (SBS/microSBS/microTBS) · Self-Etch + biological ACAD
Only 1 in vitro study (de Siqueira et al., 2020) assessed Self-Etch adhesive with biological ACAD; insufficient to perform a network meta-analysis, so no pooled estimate is reported.
1 study
GRADE not reported