Selective serotonin reuptake inhibitors vs placebo
Frequency of attacks Per week (over 2 weeks) · primary Raynaud's phenomenon
1 finding from 1 review
- no estimate extracted1 study · 41 participantsVery low
Findings
What do systematic reviews say?
31 questions · 32 findings · 6 reviews
No studies found 3 · 9.4%GRADE not reported 3 · 9.4%Very low 19 · 59.4%Low 2 · 6.3%Moderate 5 · 15.6%High 0 · 0%
Selective serotonin reuptake inhibitors vs placebo
Severity of attacks · primary Raynaud's phenomenon
1 finding from 1 review
- no estimate extracted1 study · 41 participantsVery low
Selective serotonin reuptake inhibitors vs placebo
Duration of attacks per day (minutes) · primary Raynaud's phenomenon
1 finding from 1 review
- no estimate extracted1 study · 41 participantsVery low
Selective serotonin reuptake inhibitors vs placebo
QoL · primary Raynaud's phenomenon
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Selective serotonin reuptake inhibitors vs placebo
Proportion of participants with adverse effects ‐ measured over 8 weeks · primary Raynaud's phenomenon
It is very uncertain whether selective serotonin reuptake inhibitors changes adverse events (over 4 weeks) compared with placebo (very low certainty).
1 finding from 1 review
- RR 1.54 [0.89, 2.66]1 study · 41 participantsVery low
Selective serotonin reuptake inhibitors vs placebo
RCS · primary Raynaud's phenomenon
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Selective serotonin reuptake inhibitors vs cognitive behavioural therapy
> 50% reduction in depressive symptoms · people with epilepsy and depression
1 finding from 1 review
- no estimate extracted0 studies · 0 participantsGRADE not reported
Selective serotonin reuptake inhibitors vs cognitive behavioural therapy
Depressive symptoms · people with epilepsy and depression
1 finding from 1 review
- no estimate extracted15 participantsVery low
Selective serotonin reuptake inhibitors vs cognitive behavioural therapy
Seizure frequency · people with epilepsy and depression
1 finding from 1 review
- no estimate extracted15 participantsVery low
Selective serotonin reuptake inhibitors vs cognitive behavioural therapy
Treatment withdrawal · people with epilepsy and depression
It is very uncertain whether selective serotonin reuptake inhibitors changes withdrawals compared with cognitive behavioural therapy (very low certainty).
1 finding from 1 review
- RR 0.44 [0.05, 3.85]15 participantsVery low
Selective serotonin reuptake inhibitors vs cognitive behavioural therapy
Cognitive function · people with epilepsy and depression
1 finding from 1 review
- no estimate extracted0 studies · 0 participantsGRADE not reported
Selective serotonin reuptake inhibitors vs cognitive behavioural therapy
Post‐treatment quality of life (QOLIE‐31 score, which has a range of 0‐200, with higher score indicates better quality of life) ( · people with epilepsy and depression
1 finding from 1 review
- no estimate extracted15 participantsVery low
Selective serotonin reuptake inhibitors vs cognitive behavioural therapy
Adverse effects ‐ adverse event profile · people with epilepsy and depression
1 finding from 1 review
- no estimate extracted0 studies · 0 participantsGRADE not reported
Selective serotonin reuptake inhibitors vs placebo
Outcomes (2‐6 months post‐treatment) · adults with panic disorder
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
Selective serotonin reuptake inhibitors vs placebo
Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder
Selective serotonin reuptake inhibitors may leads to lower failure to respond compared with placebo (low certainty).
1 finding from 1 review
- RR 0.75 [0.67, 0.84]21 studies · 4000 participantsLow
Selective serotonin reuptake inhibitors vs placebo
Leaving the study early · adults with panic disorder
Selective serotonin reuptake inhibitors showed no clear difference in total number of dropouts compared with placebo (moderate certainty).
1 finding from 1 review
- RR 0.99 [0.9, 1.09]23 studies · 4302 participantsModerate
Selective serotonin reuptake inhibitors vs placebo
Failure to remit at endpoint · adults with panic disorder
Selective serotonin reuptake inhibitors probably leads to lower failure to remit compared with placebo (moderate certainty).
1 finding from 1 review
- RR 0.81 [0.75, 0.88]16 studies · 3339 participantsModerate
Selective serotonin reuptake inhibitors vs placebo
panic symptoms · adults with panic disorder
2 findings from 1 review
- no estimate extracted6 studies · 1625 participantsModerate
- no estimate extracted7 studies · 1255 participantsModerate
Selective serotonin reuptake inhibitors vs placebo
Withdrawals due to adverse events · adults with panic disorder
Selective serotonin reuptake inhibitors probably leads to higher number of dropouts due to adverse effects compared with placebo (moderate certainty).
1 finding from 1 review
- RR 1.45 [1.16, 1.81]22 studies · 4131 participantsModerate
Selective serotonin reuptake inhibitors vs placebo
Subjective sleep quality or quantity · adults with insomnia
1 finding from 1 review
- no estimate extracted3 studies · 135 participantsLow