Findings

What do systematic reviews say?

13 questions · 13 findings · 2 reviews · Gynaecology and Fertility

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No studies found 2 · 15.4%GRADE not reported 1 · 7.7%Very low 0 · 0%Low 5 · 38.5%Moderate 4 · 30.8%High 1 · 7.7%

SPRM vs placebo

Uterine volume (cm³) · women with uterine fibroids

The review found no eligible studies for this question.

1 finding from 1 review

Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

SPRM vs placebo

Fibroid volume (cm³) · women with uterine fibroids

The review found no eligible studies for this question.

1 finding from 1 review

Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

SPRM vs placebo

Haemoglobin (g/dL) · women with uterine fibroids

1 finding from 1 review

Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 173 participants
High

SPRM vs placebo

Preoperative bleeding: (PBAC < 75) ulipristal acetate 5 mg · women with uterine fibroids

SPRM may leads to higher preoperative bleeding: (PBAC < 75) ulipristal acetate 5 mg compared with placebo (low certainty).

1 finding from 1 review

Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
OR 41.41 [15.26, 112.38]
1 study · 143 participants
Low

SPRM vs placebo

Preoperative bleeding: Reduction in bleeding to PBAC < 75 ulipristal acetate 10 mg · women with uterine fibroids

SPRM may leads to higher preoperative bleeding: Reduction in menstrual bleeding (PBAC < 75)… compared with placebo (low certainty).

1 finding from 1 review

Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
OR 78.83 [24.02, 258.74]
1 study · 146 participants
Low

SPRM vs placebo

Preoperative bleeding: Change in menstrual blood loss from baseline to end of treatment · women with uterine fibroids

1 finding from 1 review

Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 22 participants
Low

SPRM vs placebo

Adverse events · women with uterine fibroids

SPRM showed no clear difference in adverse events compared with placebo (low certainty).

1 finding from 1 review

Preoperative medical therapy before surgery for uterine fibroids 2017 · Cochrane Headline outcomes only
OR 0.05 [0, 1]
1 study · 241 participants
Low

SPRM vs placebo

Quality of life: change in symptom severity score · women with uterine fibroids

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 171 participants
Moderate

SPRM vs placebo

Quality of life: change in health‐related quality of life score · women with uterine fibroids

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 200 participants
Moderate

SPRM vs placebo

Abnormal uterine bleeding: change in menstrual blood loss · women with uterine fibroids

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 310 participants
Moderate

SPRM vs placebo

Abnormal uterine bleeding: amenorrhoea · women with uterine fibroids

SPRM probably leads to higher abnormal uterine bleeding: amenorrhoea compared with placebo (moderate certainty).

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
OR 82.5 [37.1, 183.9]
7 studies · 590 participants
Moderate

SPRM vs placebo

Pelvic pain · women with uterine fibroids

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 629 participants
GRADE not reported

SPRM vs placebo

Adverse effects: SPRM‐associated endometrial changes · women with uterine fibroids

SPRM may leads to higher adverse effects: SPRM‐associated endometrial changes compared with placebo (low certainty).

1 finding from 1 review

Selective progesterone receptor modulators (SPRMs) for uterine fibroids 2017 · Cochrane Headline outcomes only
OR 15.12 [6.45, 35.47]
5 studies · 405 participants
Low