S‐adenosyl methionine as monotherapy vs placebo
Change in depressive symptoms · depression in adults
1 finding from 1 review
- no estimate extracted2 studies · 142 participantsVery low
Findings
What do systematic reviews say?
15 questions · 15 findings · 1 reviews · Headline outcomes only
No studies found 3 · 20%GRADE not reported 0 · 0%Very low 3 · 20%Low 9 · 60%Moderate 0 · 0%High 0 · 0%
S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)
Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults
S‐adenosyl methionine as monotherapy may leads to lower acceptability. Participants experiencing troublesome adverse effects… compared with tricyclic antidepressant agent (low certainty).
1 finding from 1 review
- RR 0.68 [0.52, 0.88]3 studies · 604 participantsLow
S‐adenosyl methionine as monotherapy vs SSRI
Change in depressive symptoms · depression in adults
1 finding from 1 review
- no estimate extracted1 study · 129 participantsLow
S‐adenosyl methionine as monotherapy vs SSRI
Secondary outcome: acceptability of treatment · depression in adults
S‐adenosyl methionine as monotherapy showed no clear difference in acceptability Participants dropping out of treatment during the… compared with SSRI antidepressant agent (low certainty).
1 finding from 1 review
- RR 0.81 [0.57, 1.16]1 study · 129 participantsLow
S‐adenosyl methionine as monotherapy vs SSRI
> 50% reduction in depressive symptoms · depression in adults
S‐adenosyl methionine as monotherapy showed no clear difference in proportions of participants responding to treatment ≥ 50% reduction… compared with SSRI antidepressant agent (low certainty).
1 finding from 1 review
- RR 1.06 [0.66, 1.7]1 study · 129 participantsLow
S‐adenosyl methionine as monotherapy vs SSRI
Depression remission · depression in adults
S‐adenosyl methionine as monotherapy showed no clear difference in proportions of participants achieving remission depression rating… compared with SSRI antidepressant agent (low certainty).
1 finding from 1 review
- RR 1.02 [0.58, 1.77]1 study · 129 participantsLow
S‐adenosyl methionine as monotherapy vs SSRI
Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
S‐adenosyl methionine as monotherapy vs placebo
Secondary outcome: acceptability of treatment · depression in adults
S‐adenosyl methionine as monotherapy showed no clear difference in acceptability Participants dropping out of treatment during the… compared with placebo (low certainty).
1 finding from 1 review
- RR 0.88 [0.61, 1.29]2 studies · 142 participantsLow
S‐adenosyl methionine as monotherapy vs placebo
> 50% reduction in depressive symptoms · depression in adults
S‐adenosyl methionine as monotherapy showed no clear difference in proportions of participants responding to treatment ≥ 50% reduction… compared with placebo (low certainty).
1 finding from 1 review
- RR 1.77 [0.51, 6.13]2 studies · 142 participantsLow
S‐adenosyl methionine as monotherapy vs placebo
Depression remission · depression in adults
S‐adenosyl methionine as monotherapy showed no clear difference in proportions of participants achieving remission Depression rating… compared with placebo (low certainty).
1 finding from 1 review
- RR 1.69 [0.85, 3.36]1 study · 124 participantsLow
S‐adenosyl methionine as monotherapy vs placebo
Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found
S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)
Change in depressive symptoms · depression in adults
1 finding from 1 review
- no estimate extracted4 studies · 619 participantsLow
S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)
Secondary outcome: acceptability of treatment · depression in adults
It is very uncertain whether S‐adenosyl methionine as monotherapy changes acceptability Participants dropping out of treatment during the… compared with tricyclic antidepressant agent (very low certainty).
1 finding from 1 review
- RR 0.61 [0.28, 1.31]3 studies · 78 participantsVery low
S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)
> 50% reduction in depressive symptoms · depression in adults
It is very uncertain whether S‐adenosyl methionine as monotherapy changes proportions of participants responding to treatment ≥ 50% reduction… compared with tricyclic antidepressant agent (very low certainty).
1 finding from 1 review
- RR 1.14 [0.83, 1.56]4 studies · 622 participantsVery low
S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)
Depression remission · depression in adults
The review found no eligible studies for this question.
1 finding from 1 review
- no estimate extractedStudies not reportedNo studies found