Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

30 questions · 31 findings · 5 reviews · Kidney and Transplant

No studies found 4 · 12.9%GRADE not reported 0 · 0%Very low 7 · 22.6%Low 5 · 16.1%Moderate 14 · 45.2%High 1 · 3.2%

Rituximab vs no rituximab

Skin vasculitis (purpura, cutaneous ulcers or others) at 18 and 24 months: number of affected patients · hepatitis C virus‐associated mixed cryoglobulinaemia

Rituximab showed no clear difference in skin vasculitis (purpura, cutaneous ulcers or others) at 18 and 24… compared with no rituximab (moderate certainty).

1 finding from 1 review

Rituximab vs placebo or control

Relapse · SSNS in children

Rituximab probably leads to lower relapses at 6 months compared with placebo or control (moderate certainty).

2 findings from 1 review

Rituximab (B cell) + steroid vs steroids

Failure of acute rejection reversal · kidney transplant recipients: first rejection episode

Rituximab (B cell) + steroid showed no clear difference in failure of reversal of acute rejection compared with steroid alone (moderate certainty).

1 finding from 1 review