Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

168 questions · 172 findings · 12 reviews

No studies found 33 · 19.2%GRADE not reported 23 · 13.4%Very low 63 · 36.6%Low 37 · 21.5%Moderate 16 · 9.3%High 0 · 0%

RISPERIDONE DEPOT vs ATYPICAL DEPOT ANTIPSYCHOTICS (PALIPERIDONE PALMITATE)

Adverse events: Any prolactin‐related ‐ medium term · patients with schizophrenia

RISPERIDONE DEPOT showed no clear difference in adverse events: Any prolactin‐related ‐ medium term compared with ATYPICAL DEPOT ANTIPSYCHOTICS (PALIPERIDONE PALMITATE) (moderate certainty).

1 finding from 1 review

RISPERIDONE DEPOT vs ATYPICAL DEPOT ANTIPSYCHOTICS (PALIPERIDONE PALMITATE)

Adverse events: Any glucose‐related ‐ medium/long term · patients with schizophrenia

RISPERIDONE DEPOT showed no clear difference in adverse events: Any glucose‐related ‐ medium/long term compared with ATYPICAL DEPOT ANTIPSYCHOTICS (PALIPERIDONE PALMITATE) (low certainty).

1 finding from 1 review

CLOZAPINE + RISPERIDONE vs PLACEBO + CLOZAPINE

Mental state: No 20% response (as defined by PANSS/BPRS total change) · patients with schizophrenia

RISPERIDONE + CLOZAPINE showed no clear difference in mental state: no clinically significant response in psychotic… compared with PLACEBO + CLOZAPINE (low certainty).

1 finding from 1 review

CLOZAPINE + RISPERIDONE vs PLACEBO + CLOZAPINE

Global state: 2. no significant clinical improvement ‐ CGI, short term (up to 12 weeks) · patients with schizophrenia

RISPERIDONE + CLOZAPINE showed no clear difference in global state: no significant clinical improvement ‐ CGI short term compared with PLACEBO + CLOZAPINE (low certainty).

1 finding from 1 review