Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 33.3%Moderate 2 · 66.7%High 0 · 0%

Hepatotoxicity · HIV‐negative people at risk of TB infection1

Rifampicin plus isoniazid showed no clear difference in hepatotoxicity compared with isoniazid (low certainty).

1 finding from 1 review

Hepatotoxicity · HIV‐negative people at risk of TB infection1

Rifampicin plus pyrazinamide probably leads to higher hepatotoxicity compared with isoniazid (moderate certainty).

1 finding from 1 review

Hepatotoxicity:13 Grade 3 and 4 toxicity · HIV‐negative people at risk of TB infection1

Rifampicin probably leads to lower hepatotoxicity:13 Grade 3 and 4 toxicity compared with isoniazid (moderate certainty).

1 finding from 1 review