What do systematic reviews say?

Proton pump inhibitors (PPI) vs placebo or no prophylaxis

Proton pump inhibitors showed no clear difference in nosocomial pneumonia compared with placebo or no prophylaxis (low certainty).

• Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units 2018 · Cochrane Headline outcomes only
  RR 1.24 [0.77, 1.98]
  2 studies · 227 participants
  Low