Findings

What do systematic reviews say?

8 questions · 8 findings · 1 reviews · Emergency and Critical Care

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 6 · 75%Moderate 1 · 12.5%High 1 · 12.5%

Protocol‐directed sedation management vs usual care

Duration of mechanical ventilation · mechanically ventilated ICU adults and children requiring sedation management

1 finding from 1 review

Protocol‐directed sedation versus non‐protocol‐directed sedation in mechanically ventilated intensive care adults and… 2018 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 3283 participants
Low

Protocol‐directed sedation management vs usual care

ICU mortality · mechanically ventilated ICU adults and children requiring sedation management

Protocol‐directed sedation management showed no clear difference in ICU mortality compared with usual care (low certainty).

1 finding from 1 review

Protocol‐directed sedation versus non‐protocol‐directed sedation in mechanically ventilated intensive care adults and… 2018 · Cochrane Headline outcomes only
RR 0.77 [0.39, 1.5]
2 studies · 513 participants
Low

Protocol‐directed sedation management vs usual care

Hospital mortality · mechanically ventilated ICU adults and children requiring sedation management

Protocol‐directed sedation management showed no clear difference in hospital mortality compared with usual care (low certainty).

1 finding from 1 review

Protocol‐directed sedation versus non‐protocol‐directed sedation in mechanically ventilated intensive care adults and… 2018 · Cochrane Headline outcomes only
RR 0.9 [0.72, 1.13]
3 studies · 3082 participants
Low

Protocol‐directed sedation management vs usual care

Duration of ICU stay · mechanically ventilated ICU adults and children requiring sedation management

1 finding from 1 review

Protocol‐directed sedation versus non‐protocol‐directed sedation in mechanically ventilated intensive care adults and… 2018 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 3128 participants
Low

Protocol‐directed sedation management vs usual care

Length of hospital stay · mechanically ventilated ICU adults and children requiring sedation management

1 finding from 1 review

Protocol‐directed sedation versus non‐protocol‐directed sedation in mechanically ventilated intensive care adults and… 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 2927 participants
Moderate

Protocol‐directed sedation management vs usual care

Adverse event ‐ incidence of self‐extubation (in ICU) · mechanically ventilated ICU adults and children requiring sedation management

Protocol‐directed sedation management showed no clear difference in adverse event ‐ incidence of self‐extubation (in ICU) compared with usual care (high certainty).

1 finding from 1 review

Protocol‐directed sedation versus non‐protocol‐directed sedation in mechanically ventilated intensive care adults and… 2018 · Cochrane Headline outcomes only
RR 0.88 [0.55, 1.42]
2 studies · 2761 participants
High

Protocol‐directed sedation management vs usual care

Adverse event ‐ incidence of reintubation (in ICU) · mechanically ventilated ICU adults and children requiring sedation management

Protocol‐directed sedation management showed no clear difference in adverse event ‐ incidence of reintubation (in ICU) compared with usual care (low certainty).

1 finding from 1 review

Protocol‐directed sedation versus non‐protocol‐directed sedation in mechanically ventilated intensive care adults and… 2018 · Cochrane Headline outcomes only
RR 0.65 [0.35, 1.24]
1 study · 321 participants
Low

Protocol‐directed sedation management vs usual care

Incidence of tracheostomy (in ICU) · mechanically ventilated ICU adults and children requiring sedation management

Protocol‐directed sedation management showed no clear difference in incidence of tracheostomy (in ICU) compared with usual care (low certainty).

1 finding from 1 review

Protocol‐directed sedation versus non‐protocol‐directed sedation in mechanically ventilated intensive care adults and… 2018 · Cochrane Headline outcomes only
RR 0.67 [0.35, 1.3]
3 studies · 3082 participants
Low