Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

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No studies found 2 · 28.6%GRADE not reported 0 · 0%Very low 1 · 14.3%Low 4 · 57.1%Moderate 0 · 0%High 0 · 0%

Progesterone vs placebo/no treatment

Multiple pregnancy · women with oral (clomiphene citrate or letrozole) stimulation

Progesterone showed no clear difference in multiple pregnancy compared with placebo/no treatment (low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 0.58 [0.1, 3.55]
2 studies · 586 participants
Low

Progesterone vs placebo/no treatment

Multiple pregnancy rate · women with gonadotropin stimulation

Progesterone showed no clear difference in multiple pregnancy rate compared with placebo/no treatment (low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 0.72 [0.17, 3.15]
1 study · 214 participants
Low

Progesterone vs placebo/no treatment

Multiple pregnancy rate · women with gonadotropin plus oral (clomiphene citrate or letrozole) stimulation

Progesterone showed no clear difference in multiple pregnancy rate compared with placebo/no treatment (low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 1.44 [0.24, 8.49]
1 study · 290 participants
Low

Progesterone vs no treatment or placebo (route of progesterone administration)

Multiple pregnancy rate · women trying to conceive by intrauterine insemination

Progesterone showed no clear difference in multiple pregnancy per woman compared with no treatment or placebo (route of progesterone administration) (low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 0.84 [0.3, 2.34]
3 studies · 956 participants
Low

Oral progesterone vs vaginal progesterone

Multiple pregnancy rate · women trying to conceive by intrauterine insemination

The review found no eligible studies for this question.

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

300 mg vaginal progesterone vs vaginal progesterone

Multiple pregnancy rate · women trying to conceive by intrauterine insemination

It is very uncertain whether 300 mg vaginal progesterone changes multiple pregnancy rate compared with 600 mg vaginal progesterone (very low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 0.5 [0.05, 5.43]
1 study · 200 participants
Very low

Intramuscular (IM) progesterone vs vaginal progesterone

Multiple pregnancy rate · women trying to conceive by intrauterine insemination

The review found no eligible studies for this question.

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found