Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 40%Low 3 · 60%Moderate 0 · 0%High 0 · 0%

Intramuscular (IM) progesterone vs vaginal progesterone

Miscarriage · women trying to conceive by intrauterine insemination

It is very uncertain whether intramuscular (IM) progesterone changes miscarriage rate compared with vaginal progesterone (very low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 0.75 [0.43, 1.32]
1 study · 81 participants
Very low

Oral progesterone vs vaginal progesterone

Miscarriage per clinical pregnancy · women trying to conceive by intrauterine insemination

It is very uncertain whether oral progesterone changes miscarriage rate per clinical pregnancy compared with vaginal progesterone (very low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 0.58 [0.11, 3.09]
1 study · 41 participants
Very low

Progesterone vs placebo/no treatment

Miscarriage per clinical pregnancy · women with gonadotropin plus oral (clomiphene citrate or letrozole) stimulation

Progesterone showed no clear difference in miscarriage rate per clinical pregnancy compared with placebo/no treatment (low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 0.67 [0.3, 1.5]
2 studies · 123 participants
Low

Progesterone vs placebo/no treatment

Miscarriage per clinical pregnancy · women with oral (clomiphene citrate or letrozole) stimulation

Progesterone showed no clear difference in miscarriage rate per clinical pregnancy compared with placebo/no treatment (low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 0.53 [0.25, 1.14]
2 studies · 119 participants
Low

Progesterone vs placebo/no treatment

Miscarriage per clinical pregnancy · women with gonadotropin stimulation

Progesterone showed no clear difference in miscarriage rate per clinical pregnancy compared with placebo/no treatment (low certainty).

1 finding from 1 review

Luteal phase support for women trying to conceive by intrauterine insemination or sexual intercourse 2022 · Cochrane Headline outcomes only
RR 0.68 [0.24, 1.91]
2 studies · 102 participants
Low