Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews · Gut

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No studies found 0 · 0%GRADE not reported 1 · 25%Very low 1 · 25%Low 2 · 50%Moderate 0 · 0%High 0 · 0%

Probiotics and osmotic laxative vs osmotic laxative

Frequency of defecation (mean number of bowel movements per week) · children with chronic constipation without a physical explanation

1 finding from 1 review

Probiotics for treatment of chronic constipation in children 2022 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 268 participants
Low

Probiotics and osmotic laxative vs osmotic laxative

Global assessment of treatment success · children with chronic constipation without a physical explanation

Probiotics and osmotic laxative showed no clear difference in global improvement or treatment success, as defined by primary studies compared with osmotic laxative (low certainty).

1 finding from 1 review

Probiotics for treatment of chronic constipation in children 2022 · Cochrane Headline outcomes only
RR 0.95 [0.79, 1.15]
2 studies · 139 participants
Low

Probiotics and osmotic laxative vs osmotic laxative

Withdrawals due to adverse events · children with chronic constipation without a physical explanation

It is very uncertain whether probiotics and osmotic laxative changes withdrawal due to adverse events compared with osmotic laxative (very low certainty).

1 finding from 1 review

Probiotics for treatment of chronic constipation in children 2022 · Cochrane Headline outcomes only
RR 2.86 [0.12, 68.35]
3 studies · 268 participants
Very low

Probiotics and osmotic laxative vs osmotic laxative

Serious adverse events · children with chronic constipation without a physical explanation

1 finding from 1 review

Probiotics for treatment of chronic constipation in children 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 308 participants
GRADE not reported