Findings

What do systematic reviews say?

31 questions · 31 findings · 3 reviews · Gut

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No studies found 8 · 25.8%GRADE not reported 2 · 6.5%Very low 12 · 38.7%Low 9 · 29%Moderate 0 · 0%High 0 · 0%

Probiotics vs placebo

Clinical remission · people with active UC

Probiotics may leads to higher clinical remission compared with placebo (low certainty).

1 finding from 1 review

Probiotics for induction of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
RR 1.73 [1.19, 2.54]
9 studies · 594 participants
Low

Probiotics vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Disease improvement · people with active UC

The review found no eligible studies for this question.

1 finding from 1 review

Probiotics for induction of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Probiotics vs placebo

Disease improvement (based on clinical scores) · people with active UC

Probiotics may leads to higher disease improvement (based on clinical scores) compared with placebo (low certainty).

1 finding from 1 review

Probiotics for induction of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
RR 2.29 [1.13, 4.63]
2 studies · 54 participants
Low

Probiotics vs placebo

Minor adverse events · people with active UC

It is very uncertain whether probiotics changes minor adverse events compared with placebo (very low certainty).

1 finding from 1 review

Probiotics for induction of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
RR 1.04 [0.42, 2.59]
7 studies · 520 participants
Very low

Probiotics vs placebo

Serious adverse events · people with active UC

It is very uncertain whether probiotics changes serious adverse events compared with placebo (very low certainty).

1 finding from 1 review

Probiotics for induction of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
RR 0.09 [0.01, 1.66]
7 studies · 526 participants
Very low

Probiotics vs placebo

Withdrawals due to adverse events · people with active UC

Probiotics showed no clear difference in withdrawal due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Probiotics for induction of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
RR 0.85 [0.42, 1.72]
4 studies · 401 participants
Low

Probiotics vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Clinical remission · people with active UC

Probiotics showed no clear difference in clinical remission compared with 5‐aminosalicylic acid (5‐ASA) (mesalazine) (low certainty).

1 finding from 1 review

Probiotics for induction of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
RR 0.92 [0.73, 1.16]
1 study · 116 participants
Low

Probiotics vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Minor adverse events · people with active UC

It is very uncertain whether probiotics changes minor adverse events compared with 5‐aminosalicylic acid (5‐ASA) (mesalazine) (very low certainty).

1 finding from 1 review

Probiotics for induction of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
RR 1
2 studies · 192 participants
Very low

Probiotics vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Serious adverse events · people with active UC

It is very uncertain whether probiotics changes serious adverse events compared with 5‐aminosalicylic acid (5‐ASA) (mesalazine) (very low certainty).

1 finding from 1 review

Probiotics for induction of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
RR 0.21 [0.01, 4.22]
1 study · 116 participants
Very low

Probiotics vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Withdrawals due to adverse events · people with active UC

It is very uncertain whether probiotics changes withdrawal due to adverse events compared with 5‐aminosalicylic acid (5‐ASA) (mesalazine) (very low certainty).

1 finding from 1 review

Probiotics for induction of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
RR 0.21 [0.01, 4.22]
1 study · 116 participants
Very low

Probiotics vs placebo

Clinical relapse · Patients with quiescent ulcerative colitis

It is very uncertain whether probiotics changes clinical relapse (12 to 52 weeks) compared with placebo (very low certainty).

1 finding from 1 review

Probiotics for maintenance of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
RR 0.87 [0.63, 1.18]
4 studies · 361 participants
Very low

Probiotics vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Withdrawals due to adverse events · Patients with quiescent ulcerative colitis

It is very uncertain whether probiotics changes withdrawal due to adverse events (52 weeks) compared with 5‐aminosalicylic acid (5‐ASA) (mesalazine) (very low certainty).

1 finding from 1 review

Probiotics for maintenance of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
RR 1.02 [0.46, 2.25]
1 study · 222 participants
Very low

Probiotics vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Need for extra treatment · Patients with quiescent ulcerative colitis

The review found no eligible studies for this question.

1 finding from 1 review

Probiotics for maintenance of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Probiotics vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Health‐related quality of life (52 weeks) · Patients with quiescent ulcerative colitis

1 finding from 1 review

Probiotics for maintenance of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 222 participants
Low

Probiotics vs placebo

Maintenance of clinical remission · Patients with quiescent ulcerative colitis

It is very uncertain whether probiotics changes maintenance of clinical remission (52 weeks) compared with placebo (very low certainty).

1 finding from 1 review

Probiotics for maintenance of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
RR 1.16 [0.98, 1.37]
2 studies · 141 participants
Very low

Probiotics vs placebo

Serious adverse events (48 to 52 weeks) · Patients with quiescent ulcerative colitis

1 finding from 1 review

Probiotics for maintenance of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 351 participants
GRADE not reported

Probiotics vs placebo

Withdrawals due to adverse events · Patients with quiescent ulcerative colitis

1 finding from 1 review

Probiotics for maintenance of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 113 participants
GRADE not reported

Probiotics vs placebo

Need for extra treatment · Patients with quiescent ulcerative colitis

The review found no eligible studies for this question.

1 finding from 1 review

Probiotics for maintenance of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Probiotics vs placebo

Health‐related quality of life (12 weeks) · Patients with quiescent ulcerative colitis

1 finding from 1 review

Probiotics for maintenance of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 25 participants
Low

Probiotics vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Clinical relapse · Patients with quiescent ulcerative colitis

Probiotics showed no clear difference in clinical relapse (52 weeks) compared with 5‐aminosalicylic acid (5‐ASA) (mesalazine) (low certainty).

1 finding from 1 review

Probiotics for maintenance of remission in ulcerative colitis 2020 · Cochrane Headline outcomes only
RR 1.01 [0.84, 1.22]
2 studies · 452 participants
Low