Findings

What do systematic reviews say?

31 questions · 35 findings · 2 reviews

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No studies found 8 · 22.9%GRADE not reported 0 · 0%Very low 5 · 14.3%Low 16 · 45.7%Moderate 6 · 17.1%High 0 · 0%

Probiotics vs placebo

Diarrhoea (grade 2+) · participants with cancer treated with chemotherapy

Probiotics showed no clear difference in diarrhoea grade 2 or higher compared with placebo (low certainty).

1 finding from 1 review

Probiotics for the prevention or treatment of chemotherapy‐ or radiotherapy‐related diarrhoea in people with cancer 2018 · Cochrane Headline outcomes only
RR 0.67 [0.22, 2.05]
1 study · 46 participants
Low

Probiotics vs placebo

Grade 3 to 4 diarrhoea · participants with cancer treated with chemotherapy

Probiotics showed no clear difference in diarrhoea grade 3 or higher compared with placebo (low certainty).

1 finding from 1 review

Probiotics for the prevention or treatment of chemotherapy‐ or radiotherapy‐related diarrhoea in people with cancer 2018 · Cochrane Headline outcomes only
RR 0.11 [0.01, 1.95]
1 study · 46 participants
Low

Probiotics vs placebo

Diarrhoea grade 4 · participants with cancer treated with chemotherapy

Probiotics showed no clear difference in diarrhoea grade 4 compared with placebo (low certainty).

1 finding from 1 review

Probiotics for the prevention or treatment of chemotherapy‐ or radiotherapy‐related diarrhoea in people with cancer 2018 · Cochrane Headline outcomes only
RR 0.33 [0.01, 7.78]
1 study · 46 participants
Low

Probiotics vs placebo

Time to rescue medication ‐ not measured · participants with cancer treated with chemotherapy

The review found no eligible studies for this question.

1 finding from 1 review

Probiotics for the prevention or treatment of chemotherapy‐ or radiotherapy‐related diarrhoea in people with cancer 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Probiotics vs placebo

Requiring rescue medication for diarrhoea · participants with cancer treated with chemotherapy

1 finding from 1 review

Probiotics for the prevention or treatment of chemotherapy‐ or radiotherapy‐related diarrhoea in people with cancer 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 46 participants
Low

Probiotics vs placebo

Adverse events · participants with cancer treated with chemotherapy

1 finding from 1 review

Probiotics for the prevention or treatment of chemotherapy‐ or radiotherapy‐related diarrhoea in people with cancer 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 106 participants
Low

Probiotics vs placebo

All‐cause mortality · participants with cancer treated with chemotherapy

1 finding from 1 review

Probiotics for the prevention or treatment of chemotherapy‐ or radiotherapy‐related diarrhoea in people with cancer 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 128 participants
Low

Probiotics vs placebo or control

Diarrhoea (grade 2+) · People undergoing RT for pelvic cancer

Summary of findings: Probiotics may leads to lower diarrhoea (grade 2+) compared with control (placebo or no intervention) (low certainty).

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
RR 0.43 [0.22, 0.82]
5 studies · 923 participants
Low

Probiotics vs placebo or control

QoL · People undergoing RT for pelvic cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Probiotics vs placebo or control

Mean GI symptom scores · People undergoing RT for pelvic cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Probiotics vs placebo or control

Acute and late GI toxicity (grade 2+) · People undergoing RT for pelvic cancer

The review found no eligible studies for this question.

1 finding from 1 review

Interventions to reduce acute and late adverse gastrointestinal effects of pelvic radiotherapy for primary pelvic… 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found