Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

91 questions · 91 findings · 4 reviews

No studies found 34 · 37.4%GRADE not reported 1 · 1.1%Very low 34 · 37.4%Low 16 · 17.6%Moderate 6 · 6.6%High 0 · 0%

Summary of findings table ‐ Phenobarbital + bumetanide vs phenobarbital

Proportion of infants who achieve seizure control after the first loading dose of ASM · neonates with EEG‐confirmed seizures

Summary of findings table ‐ Phenobarbital + bumetanide showed no clear difference in proportion of infants who achieve seizure control after the first… compared with phenobarbital alone (low certainty).

1 finding from 1 review

Summary of findings table ‐ Phenobarbital + bumetanide vs phenobarbital

Mortality before hospital discharge · neonates with EEG‐confirmed seizures

It is very uncertain whether summary of findings table ‐ Phenobarbital + bumetanide changes mortality before hospital discharge compared with phenobarbital alone (very low certainty).

1 finding from 1 review