Findings

What do systematic reviews say?

91 questions · 91 findings · 4 reviews

Sort:Best matchNewest Highest certainty Download CSV

No studies found 34 · 37.4%GRADE not reported 1 · 1.1%Very low 34 · 37.4%Low 16 · 17.6%Moderate 6 · 6.6%High 0 · 0%

Phenobarbital vs chlorpromazine

Adverse events To discharge · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 100 participants
Low

Phenobarbital vs supportive care

Neonatal or infant mortality · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Phenobarbital vs supportive care

Neurodevelopmental disability · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Phenobarbital vs supportive care

Length of hospital stay · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Very low

Phenobarbital vs supportive care

Days' pharmacological treatment · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 62 participants
Very low

Phenobarbital vs supportive care

Adverse events To discharge · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Phenobarbital vs diazepam

Treatment failure To discharge · newborn infants with opioid withdrawal

Phenobarbital may leads to lower treatment failure To discharge compared with diazepam (low certainty).

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 0.39 [0.24, 0.62]
2 studies · 139 participants
Low

Phenobarbital vs diazepam

Seizures To discharge · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Phenobarbital and opioid vs opioid

Treatment failure To discharge · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Phenobarbital and opioid vs opioid

Seizures To discharge · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Phenobarbital and opioid vs opioid

Neonatal or infant mortality · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Phenobarbital and opioid vs opioid

Neurodevelopmental disability · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Phenobarbital and opioid vs opioid

Length of hospital stay · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Low

Phenobarbital and opioid vs opioid

Days' pharmacological treatment · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Phenobarbital and opioid vs opioid

Adverse events To discharge · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous phenobarbital vs placebo or no treatment

Recurrent seizure at 18 months · children with febrile seizures

Continuous phenobarbital showed no clear difference in recurrent seizure at 18 months compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
RR 0.77 [0.56, 1.05]
2 studies · 264 participants
Moderate

Continuous phenobarbital vs placebo or no treatment

Recurrent seizure at 24 months · children with febrile seizures

Continuous phenobarbital probably leads to lower recurrent seizure at 24 months compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
RR 0.69 [0.53, 0.89]
3 studies · 533 participants
Moderate

Continuous phenobarbital vs placebo or no treatment

Recurrent seizure at 36 months · children with febrile seizures

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous phenobarbital vs placebo or no treatment

Recurrent seizure at 48 months · children with febrile seizures

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Continuous phenobarbital vs placebo or no treatment

Recurrent seizure at 60 months or greater · children with febrile seizures

It is very uncertain whether continuous phenobarbital changes recurrent seizure at 60 months or greater compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Prophylactic drug management for febrile seizures in children 2021 · Cochrane Headline outcomes only
RR 1.5 [0.61, 3.69]
1 study · 60 participants
Very low