Findings

What do systematic reviews say?

6 questions · 7 findings · 1 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 2 · 28.6%Very low 5 · 71.4%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Pharmacological interventions vs placebo

Depression: meeting study criteria for depression at end of · people with depression after stroke

It is very uncertain whether pharmacological interventions changes depression: meeting study criteria for depression at end of… compared with placebo (very low certainty).

2 findings from 1 review

Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for treating… 2023 · Cochrane Headline outcomes only
RR 0.7 [0.55, 0.88]
8 studies · 1025 participants
Very low
Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for treating… 2023 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Pharmacological interventions vs placebo

Depression: < 50% reduction in scale scores at end of treatment (primary outcome) · people with depression after stroke

It is very uncertain whether pharmacological interventions changes depression: < 50% reduction in scale scores at end of treatment… compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for treating… 2023 · Cochrane Headline outcomes only
RR 0.48 [0.32, 0.7]
6 studies · 511 participants
Very low

Pharmacological interventions vs placebo

Depression: mean scores at end of treatment (secondary outcome) · people with depression after stroke

1 finding from 1 review

Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for treating… 2023 · Cochrane Headline outcomes only
no estimate extracted
15 studies · 1535 participants
GRADE not reported

Pharmacological interventions vs placebo

Adverse events: death ‐ at end of treatment (secondary outcome) · people with depression after stroke

It is very uncertain whether pharmacological interventions changes adverse events: death (secondary outcome) compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for treating… 2023 · Cochrane Headline outcomes only
RR 0.64 [0.2, 2.07]
9 studies · 848 participants
Very low

Pharmacological interventions vs placebo

Adverse effects (central nervous system) · people with depression after stroke

It is very uncertain whether pharmacological interventions changes adverse events: all ‐ central nervous system events (e.g. confusion,… compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for treating… 2023 · Cochrane Headline outcomes only
RR 1.55 [1.12, 2.15]
5 studies · 488 participants
Very low

Pharmacological interventions vs placebo

Gastrointestinal adverse events · people with depression after stroke

It is very uncertain whether pharmacological interventions changes adverse events: all ‐ gastrointestinal effects (e.g. constipation,… compared with placebo (very low certainty).

1 finding from 1 review

Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for treating… 2023 · Cochrane Headline outcomes only
RR 1.62 [1.19, 2.19]
4 studies · 473 participants
Very low