What do systematic reviews say?

1 questions · 1 findings · 1 reviews · Oral medicine and oral cancer

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Periodontitis vs Individuals without periodontal disease (by LOA)

Malignant transformation (oral cancer development) · Adults in case-control studies of oral cancer; people assessed for periodontitis

Periodontitis is associated with roughly a threefold higher odds of oral cancer (pooled OR 2.94, 95% CI 2.13-4.07; low certainty of evidence), though heterogeneity is moderate (I2=52.4%).

1 finding from 1 review

Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies. 2024 All outcomes
Not specified · Case-control studies conducted in Asia (n=6), Europe (n=5), USA (n=2) and other countries (n=3) · Overall (random-effects pooled estimate)
OR 2.94 [2.13, 4.07]
8 studies · 6927 participants
Low