Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 5 · 71.4%Low 2 · 28.6%Moderate 0 · 0%High 0 · 0%

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

All‐cause mortality during hospital stay · neonates with sepsis

Pentoxifylline with antibiotics (any dose or duration) may leads to lower all‐cause mortality during hospital stay compared with placebo or no intervention (low certainty).

1 finding from 1 review

Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
RR 0.57 [0.35, 0.93]
6 studies · 416 participants
Low

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Chronic lung disease · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes chronic lung disease compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
RR 1.5 [0.45, 5.05]
1 study · 120 participants
Very low

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Severe intraventricular haemorrhage · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes severe intraventricular haemorrhage compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
RR 0.75 [0.28, 2.03]
1 study · 120 participants
Very low

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Periventricular leukomalacia · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes periventricular leukomalacia compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
RR 0.5 [0.1, 2.63]
1 study · 120 participants
Very low

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Length of hospital stay · neonates with sepsis

Pentoxifylline with antibiotics (any dose or duration) showed no clear difference in length of hospital stay (LOS) in days compared with placebo or no intervention (low certainty).

1 finding from 1 review

Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 157 participants
Low

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Necrotising enterocolitis · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes necrotising enterocolitis, any Bell stage compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
RR 0.56 [0.29, 1.06]
6 studies · 405 participants
Very low

Pentoxifylline with antibiotics (any dose or duration) vs placebo or no intervention

Retinopathy of prematurity · neonates with sepsis

It is very uncertain whether pentoxifylline with antibiotics (any dose or duration) changes retinopathy of prematurity, any stage compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Pentoxifylline for treatment of sepsis and necrotising enterocolitis in neonates 2023 · Cochrane Headline outcomes only
RR 0.4 [0.08, 1.98]
1 study · 120 participants
Very low