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Evidence found and GRADE certainty

3 questions · 4 findings · 1 reviews

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Pentoxifylline vs multivitamin and mineral supplement

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
  • Interventions for managing oral submucous fibrosis 2024 · Cochrane All outcomes
    Rajendran 2006 (pentoxifylline 14 vs multivitamins 15): reported increased interincisal distance in the pentoxifylline group but no baseline data, so change could not be determined; excluded from meta-analysis.
    1 study · 29 participants
    GRADE not reported

Pentoxifylline vs Placebo or no active treatment

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

It is very uncertain whether pentoxifylline changes maximal mouth opening (interincisal distance) compared with placebo or no active treatment (very low certainty).

2 findings from 1 review

Pentoxifylline vs Spirulina

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Pentoxifylline may leads to lower maximal mouth opening (interincisal distance) compared with spirulina (low certainty).

1 finding from 1 review