Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

No studies found 0 · 0%GRADE not reported 1 · 14.3%Very low 0 · 0%Low 2 · 28.6%Moderate 4 · 57.1%High 0 · 0%

Failure to respond at endpoint (6‐12 weeks) · depression

Paroxetine showed no clear difference in failure to respond at endpoint (6‐12 weeks) compared with escitalopram (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.12 [0.76, 1.65]
2 studies · 784 participants
Moderate

Failure to respond at 1‐4 weeks · depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Failure to respond at 16‐24 weeks · depression

Paroxetine showed no clear difference in failure to respond at 16‐24 weeks compared with escitalopram (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.36 [0.87, 2.12]
1 study · 459 participants
Moderate

Failure to remit at endpoint · depression

Paroxetine showed no clear difference in failure to remit at endpoint compared with escitalopram (low certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.15 [0.6, 2.22]
2 studies · 784 participants
Low

SMD at endpoint · depression

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 772 participants
Low

Failure to complete ‐ any cause ‐ · depression

Paroxetine showed no clear difference in failure to complete ‐ any cause ‐ compared with escitalopram (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.47 [0.77, 2.79]
2 studies · 784 participants
Moderate

Participants with at least some Side Effects · depression

Paroxetine showed no clear difference in participants with at least some Side Effects compared with escitalopram (moderate certainty).

1 finding from 1 review

Paroxetine versus other anti‐depressive agents for depression 2014 · Cochrane Headline outcomes only
OR 1.28 [0.86, 1.91]
1 study · 454 participants
Moderate