Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews · Neonatal

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 100%Moderate 0 · 0%High 0 · 0%

Paracetamol vs indomethacin

Failure of PDA closure after first course of treatment (assessed by post‐treatment ECHO) · preterm infants with PDA

Paracetamol showed no clear difference in failure of PDA closure after first course of treatment (assessed by… compared with indomethacin (low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
RR 1.02 [0.78, 1.33]
4 studies · 380 participants
Low

Paracetamol vs indomethacin

All‐cause mortality during hospital stay · preterm infants with PDA

Paracetamol showed no clear difference in all‐cause mortality during initial hospital stay (by clinical… compared with indomethacin (low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
RR 0.86 [0.39, 1.92]
2 studies · 114 participants
Low

Paracetamol vs indomethacin

Necrotizing enterocolitis during initial hospital stay (by radiological diagnosis) · preterm infants with PDA

Paracetamol may leads to lower necrotizing enterocolitis during initial hospital stay (by… compared with indomethacin (low certainty).

1 finding from 1 review

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
RR 0.42 [0.19, 0.96]
4 studies · 384 participants
Low