What do systematic reviews say?

PDEI vs alpha‐blocker

PDEI showed no clear difference in adverse events compared with alpha‐blockers (low certainty).

• Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia 2018 · Cochrane Headline outcomes only
  RR 1.35 [0.8, 2.3]
  4 studies · 786 participants
  Low