Findings

What do systematic reviews say?

8 questions · 8 findings · 1 reviews · Oral Health

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 6 · 75%Low 0 · 0%Moderate 2 · 25%High 0 · 0%

MMP-20 expression · Human carious dentin

MMP-20 probably reduces in outer compared with inner carious dentin (moderate certainty).

1 finding from 1 review

MMP-9 location/depth · Human carious dentin

Opposite effect directions were reported for MMP-9 by lesion depth or location (very low certainty).

1 finding from 1 review

MMP-2 location/presence · Human carious dentin

No effect direction was found for MMP-2 by lesion depth or location (very low certainty).

1 finding from 1 review

MMP-8 location/presence · Human carious dentin

Evidence on MMP-8 by lesion depth or location was very low certainty.

1 finding from 1 review

Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
No clear single direction for MMP-8 by lesion depth/location (Kuhn 2016 NS by location; Shimada 2009 higher in outer); very low
2 studies
Very low

MMP-8 location/depth · Human ex vivo carious dentin

MMP-8 showed no statistical difference by lesion location; the evidence is very uncertain (very low certainty).

1 finding from 1 review

Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
Ex vivo (extracted teeth / clinical carious or biofilm samples)
Mixed: Kuhn 2016 no statistical difference by location; Shimada 2009 higher MMP-8 in outer vs inner carious dentin (very low certainty)
2 studies
Very low

MMP-2 location/depth · Human ex vivo carious dentin

No clear direction of MMP-2 presence by lesion depth/location was found; the evidence is very uncertain (very low certainty).

1 finding from 1 review

Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
Ex vivo (extracted teeth / clinical carious or biofilm samples)
The evidence is very uncertain about the MMP-2 location in dentin, as no effect direction was found (MMP-2 ubiquitous and variable across regions).
4 studies
Very low

MMP-20 location/depth (outer vs inner) · Human ex vivo carious dentin

MMP-20 probably decreases in outer compared with inner carious dentin (moderate certainty).

1 finding from 1 review

Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
Ex vivo (extracted teeth / clinical carious or biofilm samples)
MMP-20 probably reduces in carious outer dentin when compared to carious inner dentin (moderate certainty); MMP-20 was significantly lower in outer dentin than inner (Shimada et al., 2009).
1 study · 5 participants
Moderate

MMP-9 location/depth · Human ex vivo carious dentin

No clear direction of MMP-9 expression by lesion depth/location was found; the evidence is very uncertain (very low certainty).

1 finding from 1 review

Presence of host and bacterial-derived collagenolytic proteases in carious dentin: a systematic review of ex vivo… 2023 All outcomes
Ex vivo (extracted teeth / clinical carious or biofilm samples)
The evidence is very uncertain about the MMP-9 expression in different locations and lesion depth, as studies showed opposite effect directions.
3 studies
Very low