Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews · Headline outcomes only

No studies found 2 · 28.6%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 14.3%Moderate 4 · 57.1%High 0 · 0%

All‐cause mortality · cognitively healthy people in late life

Other NSAIDs showed no clear difference in mortality compared with placebo (moderate certainty).

1 finding from 1 review

Aspirin and other non‐steroidal anti‐inflammatory drugs for the prevention of dementia 2020 · Cochrane Headline outcomes only
RR 1.37 [0.78, 2.43]
1 study · 2528 participants
Moderate

Incidence of mild cognitive impairment · cognitively healthy people in late life

Other NSAIDs showed no clear difference in incidence of mild cognitive impairment compared with placebo (low certainty).

1 finding from 1 review

Aspirin and other non‐steroidal anti‐inflammatory drugs for the prevention of dementia 2020 · Cochrane Headline outcomes only
RR 1.28 [0.72, 2.28]
1 study · 2072 participants
Low

Activities of daily living · cognitively healthy people in late life

The review found no eligible studies for this question.

1 finding from 1 review

Aspirin and other non‐steroidal anti‐inflammatory drugs for the prevention of dementia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Health‐related quality of life · cognitively healthy people in late life

The review found no eligible studies for this question.

1 finding from 1 review

Aspirin and other non‐steroidal anti‐inflammatory drugs for the prevention of dementia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Incidence of Alzheimer's disease · cognitively healthy people in late life

Other NSAIDs showed no clear difference in incidence of Alzheimer's disease compared with placebo (moderate certainty).

1 finding from 1 review

Aspirin and other non‐steroidal anti‐inflammatory drugs for the prevention of dementia 2020 · Cochrane Headline outcomes only
RR 1.91 [0.89, 4.1]
1 study · 2125 participants
Moderate

Adverse events: myocardial infarction · cognitively healthy people in late life

Other NSAIDs showed no clear difference in adverse events –myocardial infarction compared with placebo (moderate certainty).

1 finding from 1 review

Aspirin and other non‐steroidal anti‐inflammatory drugs for the prevention of dementia 2020 · Cochrane Headline outcomes only
RR 1.21 [0.61, 2.4]
1 study · 2500 participants
Moderate

Adverse effects ‐ Stroke · cognitively healthy people in late life

Other NSAIDs showed no clear difference in adverse events – stroke compared with placebo (moderate certainty).

1 finding from 1 review

Aspirin and other non‐steroidal anti‐inflammatory drugs for the prevention of dementia 2020 · Cochrane Headline outcomes only
RR 1.82 [0.76, 4.37]
1 study · 2500 participants
Moderate