Findings

What do systematic reviews say?

4 questions · 7 findings · 1 reviews · Oral Health

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No studies found 0 · 0%GRADE not reported 7 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Oral prazepam (benzodiazepine) vs placebo

No improvement in TMJ pain on external palpation · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral prazepam (benzodiazepine) showed no clear difference in no improvement in TMJ pain on external palpation compared with placebo; GRADE not reported.

2 findings from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
8 days · 5 mg prazepam
RR 0.75 [0.47, 1.19]
1 study · 83 participants
GRADE not reported
Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
8 days · 10 mg prazepam
RR 1.10 [0.68, 1.49]
1 study · 83 participants
GRADE not reported

Oral prazepam (benzodiazepine) vs placebo

No improvement in spontaneous TMJ pain · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral prazepam (benzodiazepine) showed no clear difference in no improvement in spontaneous TMJ pain compared with placebo; GRADE not reported.

2 findings from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
8 days · 10 mg prazepam
RR 1.23 [0.81, 1.88]
1 study · 83 participants
GRADE not reported
Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
8 days · 5 mg prazepam
RR 0.79 [0.45, 1.38]
1 study · 83 participants
GRADE not reported

Oral prazepam (benzodiazepine) vs placebo

No improvement in TMJ pain during mastication · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Oral prazepam (benzodiazepine) showed no clear difference in no improvement in TMJ pain during mastication compared with placebo; GRADE not reported.

2 findings from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
8 days · 10 mg prazepam
RR 1.18 [0.79, 1.77]
1 study · 83 participants
GRADE not reported
Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
8 days · 5 mg prazepam
RR 0.97 [0.61, 1.54]
1 study · 83 participants
GRADE not reported

Oral prazepam (benzodiazepine) vs placebo

Adverse events (reported; mild, no withdrawals) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

1 finding from 1 review

Pharmacological interventions for pain in patients with temporomandibular disorders 2010 · Cochrane All outcomes
8 days
Rossi et al 1983 (prazepam) reported adverse effects. Per the review's Adverse effects of interventions section: 'All but one study (Lobo et al 2004) reported adverse effects. Most of the reported adverse effects were…
1 study · 83 participants
GRADE not reported