What do systematic reviews say?

Oral misoprostol 20 µg hourly titrated vs oral misoprostol 25 µg two‐hourly static

It is very uncertain whether oral misoprostol 20 µg hourly titrated changes apgar score less than 7 at 5 minutes compared with oral misoprostol 25 µg two‐hourly static (very low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 1 [0.32, 3.16]
  2 studies · 296 participants
  Very low