Findings

What do systematic reviews say?

49 questions · 49 findings · 1 reviews · Pregnancy and Childbirth

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No studies found 1 · 2%GRADE not reported 0 · 0%Very low 23 · 46.9%Low 20 · 40.8%Moderate 5 · 10.2%High 0 · 0%

Oral misoprostol vs placebo/no treatment

Vaginal birth within 24 hours · women with ruptured membranes in the third trimester for induction of labour.

The review found no eligible studies for this question.

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral misoprostol vs vaginal dinoprostone

Uterine hyperstimulation with fetal heart rate changes · women in the third trimester for induction of labour.

Oral misoprostol may leads to lower uterine hyperstimulation with fetal heart rate changesÂ compared with vaginal dinoprostone (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.49 [0.4, 0.59]
11 studies · 9084 participants
Low

Oral misoprostol vs vaginal dinoprostone

Oxytocin augmentation · women in the third trimester for induction of labour.

It is very uncertain whether oral misoprostol changes oxytocin augmentationÂ compared with vaginal dinoprostone (very low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.9 [0.75, 1.09]
12 studies · 9451 participants
Very low

Oral misoprostol vs vaginal dinoprostone

Uterine hyperstimulation without fetal heart rate changes · women in the third trimester for induction of labour.

Oral misoprostol probably leads to lower uterine hyperstimulation without fetal heart rate changesÂ compared with vaginal dinoprostone (moderate certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.83 [0.72, 0.97]
9 studies · 8171 participants
Moderate

Oral misoprostol vs vaginal dinoprostone

Apgar score less than 7 at 5 minutes · women in the third trimester for induction of labour.

Oral misoprostol showed no clear difference in apgar score less than seven at five minutesÂ compared with vaginal dinoprostone (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.8 [0.52, 1.23]
12 studies · 9473 participants
Low

Oral misoprostol vs vaginal dinoprostone

Admission to neonatal intensive care unit · women in the third trimester for induction of labour.

Oral misoprostol showed no clear difference in admission to neonatal intensive care unitÂ compared with vaginal dinoprostone (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.8 [0.6, 1.07]
11 studies · 9278 participants
Low

Oral misoprostol vs vaginal misoprostol

Vaginal birth within 24 hours · women in the third trimester for induction of labour.

Oral misoprostol may leads to lower vaginal birth within 24 hoursÂ compared with vaginal misoprostol (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.81 [0.68, 0.95]
16 studies · 3451 participants
Low

Oral misoprostol vs vaginal misoprostol

Caesarean section · women in the third trimester for induction of labour.

Oral misoprostol showed no clear difference in caesarean section compared with vaginal misoprostol (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 1 [0.86, 1.16]
32 studies · 5914 participants
Low

Oral misoprostol vs vaginal misoprostol

Uterine hyperstimulation with fetal heart rate changes · women in the third trimester for induction of labour.

Oral misoprostol may leads to lower uterine hyperstimulation with fetal heart rate changesÂ compared with vaginal misoprostol (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.69 [0.53, 0.92]
25 studies · 4857 participants
Low

Oral misoprostol vs vaginal misoprostol

Oxytocin augmentation · women in the third trimester for induction of labour.

Oral misoprostol may leads to higher oxytocin augmentationÂ compared with vaginal misoprostol (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 1.28 [1.15, 1.44]
28 studies · 5416 participants
Low

Oral misoprostol vs vaginal misoprostol

Uterine hyperstimulation without fetal heart rate changes · women in the third trimester for induction of labour.

Oral misoprostol may leads to lower uterine hyperstimulation without fetal heart rate changesÂ compared with vaginal misoprostol (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.69 [0.49, 0.99]
16 studies · 3212 participants
Low

Oral misoprostol vs placebo/no treatment

Caesarean section · women with ruptured membranes in the third trimester for induction of labour.

Oral misoprostol showed no clear difference in caesarean section compared with placebo/no treatment (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.81 [0.59, 1.11]
4 studies · 594 participants
Low

Oral misoprostol vs vaginal misoprostol

Apgar score less than 7 at 5 minutes · women in the third trimester for induction of labour.

Oral misoprostol showed no clear difference in apgar score less than seven at five minutesÂ compared with vaginal misoprostol (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.68 [0.46, 1.02]
21 studies · 4438 participants
Low

Oral misoprostol vs vaginal misoprostol

Admission to neonatal intensive care unit · women in the third trimester for induction of labour.

Oral misoprostol showed no clear difference in admission to neonatal intensive care unitÂ compared with vaginal misoprostol (moderate certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 1.03 [0.86, 1.23]
23 studies · 4450 participants
Moderate

Oral misoprostol vs intravenous (IV) oxytocin

Vaginal birth within 24 hours · women in the third trimester for induction of labour.

Oral misoprostol showed no clear difference in vaginal birth within 24 hours compared with intravenous oxytocin (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 1.12 [0.95, 1.33]
3 studies · 466 participants
Low

Oral misoprostol vs intravenous (IV) oxytocin

Caesarean section · women in the third trimester for induction of labour.

Oral misoprostol probably leads to lower caesarean section compared with intravenous oxytocin (moderate certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.67 [0.5, 0.9]
6 studies · 737 participants
Moderate

Oral misoprostol vs intravenous (IV) oxytocin

Uterine hyperstimulation with fetal heart rate changes · women in the third trimester for induction of labour.

It is very uncertain whether oral misoprostol changes uterine hyperstimulation with fetal heart rate changes compared with intravenous oxytocin (very low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.66 [0.19, 2.26]
3 studies · 331 participants
Very low

Oral misoprostol vs intravenous (IV) oxytocin

Oxytocin augmentation · women in the third trimester for induction of labour.

Oral misoprostol may leads to lower oxytocin augmentation compared with intravenous oxytocin (low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 0.12 [0.02, 0.85]
3 studies · 261 participants
Low

Oral misoprostol vs intravenous (IV) oxytocin

Uterine hyperstimulation without fetal heart rate changes · women in the third trimester for induction of labour.

It is very uncertain whether oral misoprostol changes uterine hyperstimulation without fetal heart rate changesÂ compared with intravenous oxytocin (very low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 6 [0.76, 47.6]
2 studies · 220 participants
Very low

Oral misoprostol vs intravenous (IV) oxytocin

Apgar score less than 7 at 5 minutes · women in the third trimester for induction of labour.

It is very uncertain whether oral misoprostol changes apgar score less than 7 at 5 minutes compared with intravenous oxytocin (very low certainty).

1 finding from 1 review

Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
RR 2.05 [0.27, 15.7]
4 studies · 527 participants
Very low