What do systematic reviews say?

Oral misoprostol vs vaginal dinoprostone

Oral misoprostol showed no clear difference in admission to neonatal intensive care unit compared with vaginal dinoprostone (low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 0.8 [0.6, 1.07]
  11 studies · 9278 participants
  Low

Oral misoprostol vs vaginal misoprostol

Oral misoprostol showed no clear difference in admission to neonatal intensive care unit compared with vaginal misoprostol (moderate certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 1.03 [0.86, 1.23]
  23 studies · 4450 participants
  Moderate

Oral misoprostol vs intravenous (IV) oxytocin

It is very uncertain whether oral misoprostol changes admission to neonatal intensive care unit compared with intravenous oxytocin (very low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 0.65 [0.12, 3.45]
  4 studies · 517 participants
  Very low

Oral misoprostol vs mechanical methods

Oral misoprostol showed no clear difference in admission to neonatal intensive care unit compared with mechanical methods (low certainty).

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  RR 1.24 [0.87, 1.76]
  5 studies · 2886 participants
  Low

Oral misoprostol vs placebo/no treatment

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 130 participants
  Very low

Oral misoprostol one‐ to two‐hourly vs oral misoprostol four‐ to six‐hourly

• Low‐dose oral misoprostol for induction of labour 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 64 participants
  Very low