Findings

What do systematic reviews say?

12 questions · 12 findings · 1 reviews · Gynaecology and Fertility

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No studies found 4 · 33.3%GRADE not reported 0 · 0%Very low 4 · 33.3%Low 4 · 33.3%Moderate 0 · 0%High 0 · 0%

Oral contraceptive pill (OCP) vs metformin combined with OCP

Hirsutism ‐ Clinical F‐G score · aAdult women with PCOS

1 finding from 1 review

Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 389 participants
Low

Oral contraceptive pill (OCP) vs metformin combined with OCP

Adverse events ‐ Severe · aAdult women with PCOS

Oral contraceptive pill (OCP) may leads to lower adverse events ‐ Severe compared with metformin combined with OCP (low certainty).

1 finding from 1 review

Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
OR 0.2 [0.06, 0.72]
5 studies · 228 participants
Low

Oral contraceptive pill (OCP) vs metformin combined with OCP

Minor adverse events · aAdult women with PCOS

Oral contraceptive pill (OCP) may leads to lower adverse events ‐ Minor compared with metformin combined with OCP (low certainty).

1 finding from 1 review

Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
OR 0.06 [0.01, 0.44]
2 studies · 98 participants
Low

Oral contraceptive pill (OCP) vs metformin combined with OCP

Improved menstrual pattern · aAdult women with PCOS

The review found no eligible studies for this question.

1 finding from 1 review

Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral contraceptive pill (OCP) vs metformin combined with OCP

Acne ‐ Clinical acne score · aAdult women with PCOS

1 finding from 1 review

Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 82 participants
Low

Oral contraceptive pill (OCP) vs metformin combined with OCP

Body‐mass index (BMI) · aAdult women with PCOS

1 finding from 1 review

Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 661 participants
Very low

Oral contraceptive pill (OCP) vs metformin combined with OCP

Hirsutism ‐ Clinical F‐G score · adolescent women with PCOS

1 finding from 1 review

Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 32 participants
Very low

Oral contraceptive pill (OCP) vs metformin combined with OCP

Adverse events ‐ Severe · adolescent women with PCOS

It is very uncertain whether oral contraceptive pill (OCP) changes adverse events ‐ Severe compared with metformin combined with OCP (very low certainty).

1 finding from 1 review

Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
OR 1 [0.06, 17.33]
1 study · 36 participants
Very low

Oral contraceptive pill (OCP) vs metformin combined with OCP

Minor adverse events · adolescent women with PCOS

The review found no eligible studies for this question.

1 finding from 1 review

Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral contraceptive pill (OCP) vs metformin combined with OCP

Improved menstrual pattern · adolescent women with PCOS

The review found no eligible studies for this question.

1 finding from 1 review

Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral contraceptive pill (OCP) vs metformin combined with OCP

Acne ‐ Visual analogue scale or Clinical acne score · adolescent women with PCOS

The review found no eligible studies for this question.

1 finding from 1 review

Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral contraceptive pill (OCP) vs metformin combined with OCP

Body‐mass index (BMI) · adolescent women with PCOS

1 finding from 1 review

Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary… 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 32 participants
Very low