What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Periodontology

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No studies found 0 · 0%GRADE not reported 6 · 100%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Oral cancer patients (cases) vs Healthy controls

Periodontal parameters (all measures pooled) in OC cases vs controls · Adults in case-control studies (oral cancer patients vs healthy controls)

Pooling all periodontal measures, oral cancer patients had worse periodontal status than controls (SMD 0.95, 95% CI 0.41-1.49; very high heterogeneity, I2=96.8%); ungraded. Note this pools clinically different measures.

1 finding from 1 review

Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies. 2024 All outcomes
Not specified · Case-control studies conducted in Asia (n=6), Europe (n=5), USA (n=2) and other countries (n=3) · Overall (all periodontal measures pooled)
SMD 0.95 [0.41, 1.49]
5 studies
GRADE not reported

Oral cancer patients (cases) vs Healthy controls

Probing pocket depth · Adults in case-control studies (oral cancer patients vs healthy controls)

Periodontal pocket depth did not differ significantly between oral cancer patients and controls (SMD 1.64, 95% CI -0.20 to 3.47; very high heterogeneity); ungraded.

1 finding from 1 review

Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies. 2024 All outcomes
Not specified · Case-control studies conducted in Asia (n=6), Europe (n=5), USA (n=2) and other countries (n=3) · PPD (periodontal pocket depth)
SMD 1.64 [-0.20, 3.47]
2 studies
GRADE not reported

Oral cancer patients (cases) vs Healthy controls

Alveolar bone loss · Adults in case-control studies (oral cancer patients vs healthy controls)

Alveolar bone loss did not differ significantly between oral cancer patients and controls (SMD 0.18, 95% CI -2.34 to 2.69; extreme heterogeneity); ungraded.

1 finding from 1 review

Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies. 2024 All outcomes
Not specified · Case-control studies conducted in Asia (n=6), Europe (n=5), USA (n=2) and other countries (n=3) · ABL (alveolar bone loss)
SMD 0.18 [-2.34, 2.69]
2 studies
GRADE not reported

Oral cancer patients (cases) vs Healthy controls

Dental caries · Adults in case-control studies (oral cancer patients vs healthy controls)

The DMFT index was significantly higher in oral cancer patients than controls (SMD 0.65, 95% CI 0.12-1.18); ungraded.

1 finding from 1 review

Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies. 2024 All outcomes
Not specified · Case-control studies conducted in Asia (n=6), Europe (n=5), USA (n=2) and other countries (n=3) · DMFT (decayed, missing, filled teeth)
SMD 0.65 [0.12, 1.18]
2 studies
GRADE not reported

Oral cancer patients (cases) vs Healthy controls

Mean number of missing teeth in OC cases vs controls · Adults in case-control studies (oral cancer patients vs healthy controls)

The mean number of missing teeth did not differ significantly between oral cancer patients and controls (SMD 0.59, 95% CI -0.04 to 1.22); ungraded.

1 finding from 1 review

Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies. 2024 All outcomes
Not specified · Case-control studies conducted in Asia (n=6), Europe (n=5), USA (n=2) and other countries (n=3) · Missing teeth (mean count)
SMD 0.59 [-0.04, 1.22]
3 studies
GRADE not reported

Oral cancer patients (cases) vs Healthy controls

Periodontitis (clinical attachment loss) · Adults in case-control studies (oral cancer patients vs healthy controls)

Clinical attachment loss was significantly greater in oral cancer patients than controls (SMD 1.94, 95% CI 0.22-3.66), though heterogeneity was very high (I2=96.7%); ungraded.

1 finding from 1 review

Periodontitis and the risk of oral cancer: a meta-analysis of case-control studies. 2024 All outcomes
Not specified · Case-control studies conducted in Asia (n=6), Europe (n=5), USA (n=2) and other countries (n=3) · CAL (clinical attachment loss)
SMD 1.94 [0.22, 3.66]
2 studies
GRADE not reported