Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 1 · 20%Moderate 4 · 80%High 0 · 0%

Oral vs IV antibiotics

All‐cause mortality · people with cancer who have febrile neutropenia

Oral showed no clear difference in mortality compared with intravenous antibiotic therapy (moderate certainty).

1 finding from 1 review

Oral versus intravenous antibiotic treatment for febrile neutropenia in cancer patients 2013 · Cochrane Headline outcomes only
RR 0.95 [0.54, 1.68]
9 studies · 1392 participants
Moderate

Oral vs IV antibiotics

Treatment failure · people with cancer who have febrile neutropenia

Oral showed no clear difference in treatment failure compared with intravenous antibiotic therapy (moderate certainty).

1 finding from 1 review

Oral versus intravenous antibiotic treatment for febrile neutropenia in cancer patients 2013 · Cochrane Headline outcomes only
RR 0.96 [0.86, 1.06]
22 studies · 3142 participants
Moderate

Oral vs IV antibiotics

Treatment failure ‐ per protocol analysis · people with cancer who have febrile neutropenia

Oral showed no clear difference in treatment failure ‐ per protocol analysis compared with intravenous antibiotic therapy (moderate certainty).

1 finding from 1 review

Oral versus intravenous antibiotic treatment for febrile neutropenia in cancer patients 2013 · Cochrane Headline outcomes only
RR 0.98 [0.86, 1.11]
22 studies · 2912 participants
Moderate

Oral vs IV antibiotics

Adverse events requiring discontinuation of antibiotics · people with cancer who have febrile neutropenia

Oral showed no clear difference in adverse events requiring discontinuation of antibiotics compared with intravenous antibiotic therapy (low certainty).

1 finding from 1 review

Oral versus intravenous antibiotic treatment for febrile neutropenia in cancer patients 2013 · Cochrane Headline outcomes only
RR 1.45 [0.61, 3.46]
15 studies · 1823 participants
Low

Oral vs IV antibiotics

Treatment failure not dt modification in update · people with cancer who have febrile neutropenia

Oral showed no clear difference in treatment failure not dt modification in update compared with intravenous antibiotic therapy (moderate certainty).

1 finding from 1 review

Oral versus intravenous antibiotic treatment for febrile neutropenia in cancer patients 2013 · Cochrane Headline outcomes only
RR 0.95 [0.85, 1.06]
21 studies · 3041 participants
Moderate