evidencegaps
Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

1,809 questions · 1,956 findings · 194 reviews

Sort:Best matchNewestHighest certaintyDownload CSV
No studies found 422 · 21.6%GRADE not reported 427 · 21.8%Very low 353 · 18%Low 397 · 20.3%Moderate 293 · 15%High 64 · 3.3%

Chloral hydrate oral (60 mg/kg) vs music therapy

Proportion of children who had sedation failure or inadequate level of sedation · children undergoing neurodiagnostic procedures

It is very uncertain whether chloral hydrate oral (60 mg/kg) changes proportion of children who had sedation failure or inadequate level… compared with music therapy (very low certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs sodium thiopental rectal (25 mg/kg)

Proportion of children who successfully completed neurodiagnostic procedure without interruption by the child awakening · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in proportion of children who successfully completed neurodiagnostic… compared with sodium thiopental rectal (25 mg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs sodium thiopental rectal (25 mg/kg)

Proportion of children who had sedation failure or inadequate level of sedation · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in proportion of children who had sedation failure or inadequate level… compared with sodium thiopental rectal (25 mg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs sodium thiopental rectal (25 mg/kg)

Number of children with clinical adverse event: oxygen desaturation · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in number of children with clinical adverse event: desaturation compared with sodium thiopental rectal (25 mg/kg) (low certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs sodium thiopental rectal (25 mg/kg)

Number of children with clinical adverse event: diarrhoea · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) probably leads to lower number of children with clinical adverse event: diarrhoea compared with sodium thiopental rectal (25 mg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs dexmedetomidine intranasal (3 μg/kg)

Bradycardia · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) leads to lower number of children with clinical adverse event: bradycardia compared with dexmedetomidine intranasal (3 μg/kg) (high certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs dexmedetomidine intranasal (3 μg/kg)

Number of children with clinical adverse event: unsteadiness within 24 h after discharge · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in number of children with clinical adverse event: unsteadiness within… compared with dexmedetomidine intranasal (3 μg/kg) (low certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs dexmedetomidine intranasal (3 μg/kg)

Number of children with clinical adverse event: crying during administration of sedation · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) probably leads to higher number of children with clinical adverse event: crying during… compared with dexmedetomidine intranasal (3 μg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs dexmedetomidine intranasal (3 μg/kg)

Vomiting · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in number of children with clinical adverse event: vomiting compared with dexmedetomidine intranasal (3 μg/kg) (low certainty).

1 finding from 1 review

Chloral hydrate oral (75 mg/kg) vs pentobarbital intravenous (5 mg/kg)

Proportion of children who required a further dose of either the same sedative agent or the addition of a different sedative agent · children undergoing neurodiagnostic procedures

The review found no eligible studies for this question.

1 finding from 1 review