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Evidence found and GRADE certainty

1,809 questions · 1,956 findings · 194 reviews

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No studies found 422 · 21.6%GRADE not reported 427 · 21.8%Very low 353 · 18%Low 397 · 20.3%Moderate 293 · 15%High 64 · 3.3%

Chloral hydrate oral (50 mg/kg) vs melatonin oral

Number of children with clinical adverse events (any) · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in number of children with clinical adverse events (any) compared with melatonin oral (low certainty).

1 finding from 1 review

Chloral hydrate oral (70 mg/kg) vs promethazine

Proportion of children with inadequate level of sedation (Ramsay score below 4) · children undergoing neurodiagnostic procedures

Chloral hydrate oral (70 mg/kg) may leads to lower proportion of children with inadequate level of sedation (Ramsay… compared with promethazine oral (1 mg/kg) (low certainty).

1 finding from 1 review

Chloral hydrate oral (70 mg/kg) vs promethazine

Proportion of children who had sedation failure or inadequate level of sedation · children undergoing neurodiagnostic procedures

Chloral hydrate oral (70 mg/kg) probably leads to lower proportion of children who had sedation failure or inadequate level… compared with promethazine oral (1 mg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (70 mg/kg) vs promethazine

Number of children with clinical adverse event: behavioural change · children undergoing neurodiagnostic procedures

Chloral hydrate oral (70 mg/kg) showed no clear difference in number of children with clinical adverse event: behavioural change compared with promethazine oral (1 mg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (70 mg/kg) vs promethazine

Number of children with clinical adverse event: nausea or vomiting · children undergoing neurodiagnostic procedures

Chloral hydrate oral (70 mg/kg) showed no clear difference in number of children with clinical adverse event: vomiting or nausea compared with promethazine oral (1 mg/kg) (low certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs clonidine oral (4 μg/kg)

Number of children with clinical adverse event: drowsiness · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) probably leads to lower number of children with clinical adverse event: drowsiness compared with clonidine oral (4 μg/kg) (moderate certainty).

1 finding from 1 review

Chloral hydrate oral (50 mg/kg) vs clonidine oral (4 μg/kg)

Number of children with clinical adverse event: vertigo · children undergoing neurodiagnostic procedures

Chloral hydrate oral (50 mg/kg) showed no clear difference in number of children with clinical adverse event: vertigo compared with clonidine oral (4 μg/kg) (moderate certainty).

1 finding from 1 review

Primary school-based behavioural intervention (both oral hygiene and dietary components) vs No treatment (or delayed treatment)

Change in oral health knowledge and skills · Children aged 4 to 12 years attending primary school
1 finding from 1 review

Oral midazolam vs chloral hydrate

Level of sedation on a sedation assessment scale · children requiring sedation before procedures that require motion control, including echocardiography, lumbar puncture, micturating…
1 finding from 1 review