Findings

What do systematic reviews say?

8 questions · 8 findings · 5 reviews

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No studies found 2 · 25%GRADE not reported 0 · 0%Very low 3 · 37.5%Low 2 · 25%Moderate 1 · 12.5%High 0 · 0%

Oral plus intravenous acetylcysteine vs intravenous acetylcysteine

All‐cause mortality · people with paracetamol (acetaminophen) overdose

1 finding from 1 review

Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Very low

Subcutaneous EPO with intravenous iron and oral iron vs intravenous iron with oral iron (Comparison 12)

Maternal mortality ‐ not reported · women with postpartum iron deficiency anaemia

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for women with postpartum iron deficiency anaemia 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intravenous iron with oral iron vs oral iron

Maternal death · women with postpartum iron deficiency anaemia

The review found no eligible studies for this question.

1 finding from 1 review

Treatment for women with postpartum iron deficiency anaemia 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral vs IV antibiotics

All‐cause mortality · people with cancer who have febrile neutropenia

Oral showed no clear difference in mortality compared with intravenous antibiotic therapy (moderate certainty).

1 finding from 1 review

Oral versus intravenous antibiotic treatment for febrile neutropenia in cancer patients 2013 · Cochrane Headline outcomes only
RR 0.95 [0.54, 1.68]
9 studies · 1392 participants
Moderate

Oral vs intravenous acetylcysteine

All‐cause mortality · people with paracetamol (acetaminophen) overdose

1 finding from 1 review

Interventions for paracetamol (acetaminophen) overdose 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 66 participants
Very low

Partial oral treatment vs conventional intravenous treatment of endocarditis on the left side of the heart (on native or prosthetic valves) and bacteraemia

All‐cause mortality during hospital stay and all‐cause mortality at 1 year · people with endocarditis on the left side of the heart (on native or prosthetic valves) with bacteraemia for Streptococcus, Enterococcus…

It is very uncertain whether partial oral treatment changes all‐cause mortality during hospital stay and all‐cause mortality at… compared with conventional intravenous treatment of endocarditis on the left side… (very low certainty).

1 finding from 1 review

A comparison of different antibiotic regimens for the treatment of infective endocarditis 2020 · Cochrane Headline outcomes only
RR 0.53 [0.22, 1.31]
1 study · 400 participants
Very low

IV or oral iron alone vs no treatment

Overall mortality4 (Subnet based on 71 studies including 21,576 participants) · patients at any age with solid cancer or haematological malignancy

IV or oral iron alone showed no clear difference in overall mortality4 (Subnet based on 71 studies including 21,576… compared with no treatment (low certainty).

1 finding from 1 review

Intravenous iron versus oral iron versus no iron with or without erythropoiesis‐ stimulating agents (ESA) for cancer… 2022 · Cochrane Headline outcomes only
RR 1.5 [0.63, 3.56]
Studies not reported
Low

IV or oral iron alone vs no treatment

On‐study mortality3 (Subnet based on 55 studies including 15,074 participants) · patients at any age with solid cancer or haematological malignancy

IV or oral iron alone showed no clear difference in on‐study mortality3 (Subnet based on 55 studies including 15,074… compared with no treatment (low certainty).

1 finding from 1 review

Intravenous iron versus oral iron versus no iron with or without erythropoiesis‐ stimulating agents (ESA) for cancer… 2022 · Cochrane Headline outcomes only
RR 2.95 [0.71, 12.34]
Studies not reported
Low