Findings

What do systematic reviews say?

21 questions · 21 findings · 2 reviews

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No studies found 7 · 33.3%GRADE not reported 0 · 0%Very low 7 · 33.3%Low 6 · 28.6%Moderate 1 · 4.8%High 0 · 0%

Phenobarbital and opioid vs opioid

Treatment failure To discharge · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Phenobarbital and opioid vs opioid

Seizures To discharge · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Phenobarbital and opioid vs opioid

Neonatal or infant mortality · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Phenobarbital and opioid vs opioid

Neurodevelopmental disability · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Phenobarbital and opioid vs opioid

Length of hospital stay · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Low

Phenobarbital and opioid vs opioid

Days' pharmacological treatment · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Phenobarbital and opioid vs opioid

Adverse events To discharge · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs phenobarbital

Treatment failure To discharge · newborn infants with opioid withdrawal

Opioid probably leads to lower treatment failure To discharge compared with phenobarbital (moderate certainty).

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 0.51 [0.35, 0.74]
6 studies · 458 participants
Moderate

Opioids vs phenobarbital

Seizures To discharge · newborn infants with opioid withdrawal

It is very uncertain whether opioid changes seizures To discharge compared with phenobarbital (very low certainty).

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 0.08 [0, 1.44]
3 studies · 281 participants
Very low

Opioids vs phenobarbital

Neonatal or infant mortality · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs phenobarbital

Neurodevelopmental disability · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Opioids vs phenobarbital

Length of hospital stay · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 166 participants
Low

Opioids vs phenobarbital

Days treatment · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 349 participants
Low

Opioids vs phenobarbital

Adverse events (treatment related) To discharge · newborn infants with opioid withdrawal

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 96 participants
Low

Clonidine and opioid vs phenobarbital and opioid

Treatment failure To discharge · newborn infants with opioid withdrawal

It is very uncertain whether clonidine and opioid changes treatment failure To discharge compared with phenobarbital and opioid (very low certainty).

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 2.27 [0.98, 5.25]
2 studies · 93 participants
Very low

Clonidine and opioid vs phenobarbital and opioid

Seizures To discharge · newborn infants with opioid withdrawal

It is very uncertain whether clonidine and opioid changes seizures To discharge compared with phenobarbital and opioid (very low certainty).

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 3 [0.13, 71.15]
1 study · 68 participants
Very low

Clonidine and opioid vs phenobarbital and opioid

Mortality before hospital discharge · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 68 participants
Very low

Clonidine and opioid vs phenobarbital and opioid

Neurodevelopmental disability · newborn infants with opioid withdrawal

The review found no eligible studies for this question.

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Clonidine and opioid vs phenobarbital and opioid

Length of hospital stay · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 91 participants
Low

Clonidine and opioid vs phenobarbital and opioid

Days' pharmacological treatment · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 91 participants
Low