Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 66.7%Low 0 · 0%Moderate 1 · 33.3%High 0 · 0%

Treatment failure To discharge · newborn infants with opioid withdrawal

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Treatment failure To discharge · newborn infants with opioid withdrawal

Opioid probably leads to lower treatment failure To discharge compared with phenobarbital (moderate certainty).

1 finding from 1 review

Opioid treatment for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 0.51 [0.35, 0.74]
6 studies · 458 participants
Moderate

Treatment failure To discharge · newborn infants with opioid withdrawal

It is very uncertain whether clonidine and opioid changes treatment failure To discharge compared with phenobarbital and opioid (very low certainty).

1 finding from 1 review

Sedatives for opioid withdrawal in newborn infants 2021 · Cochrane Headline outcomes only
RR 2.27 [0.98, 5.25]
2 studies · 93 participants
Very low