What do systematic reviews say?

Non‐selective NSAIDs vs selective cyclo‐oxygenase‐2 inhibitors

Non‐selective NSAIDs probably leads to higher withdrawals due to adverse events compared with selective cyclo‐oxygenase‐2 inhibitors (moderate certainty).

• Non‐steroidal anti‐inflammatory drugs for acute gout 2021 · Cochrane Headline outcomes only
  RR 2.34 [1.33, 4.14]
  Studies not reported
  Moderate