What do systematic reviews say?

Non‐invasive ventilation vs usual care

Non‐invasive ventilation probably leads to lower mortality compared with usual medical care (moderate certainty).

• Non‐invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic… 2017 · Cochrane Headline outcomes only
  RR 0.54 [0.38, 0.76]
  12 studies · 854 participants
  Moderate

Non‐invasive ventilation vs usual care

Non‐invasive ventilation probably leads to lower need for endotracheal intubation compared with usual medical care (moderate certainty).

• Non‐invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic… 2017 · Cochrane Headline outcomes only
  RR 0.36 [0.28, 0.46]
  17 studies · 1105 participants
  Moderate

Non‐invasive ventilation vs usual care

• Non‐invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 888 participants
  Moderate