Nano-hydroxyapatite (nHA) dentifrice/paste (fluoride-free or fluoridated) vs nHA-free / fluoride-free (negative) control
Mineral loss (transversal microradiography) · Enamel/dentin specimens with initial caries lesions (or sound surfaces) in intraoral (in situ) appliances worn by patients
Under remineralizing conditions, nHA produced significantly more remineralization than the negative control (MD 350, 95% CI 179 to 521; very low certainty).
2 findings from 1 review
- Efficacy of nano-hydroxyapatite on caries prevention-a systematic review and meta-analysis. 2022 All outcomesMedian 21 days (range 14-28 days) · In situ (intraoral appliance); net-remineralizing model · Net-remineralizing conditionsMD 350 [179, 521]1 studyVery low
- Efficacy of nano-hydroxyapatite on caries prevention-a systematic review and meta-analysis. 2022 All outcomesMedian 21 days (range 14-28 days) · In situ (intraoral appliance); net-demineralizing model · Net-demineralizing conditionsMD -61 [-1301, 1179]1 studyVery low