Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

18 questions · 18 findings · 2 reviews

No studies found 12 · 66.7%GRADE not reported 1 · 5.6%Very low 2 · 11.1%Low 3 · 16.7%Moderate 0 · 0%High 0 · 0%

Naloxone + oxycodone prolonged release tablets vs oxycodone

Laxation response: risk of spontaneous rescue‐free bowel movements in the short terma · people with cancer irrespective of whether they were receiving palliative care opioid‐induced bowel dysfunction

The review found no eligible studies for this question.

1 finding from 1 review

Naloxone + oxycodone prolonged release tablets vs oxycodone

Laxation response: risk of spontaneous rescue‐free bowel movements in the medium termb · people with cancer irrespective of whether they were receiving palliative care opioid‐induced bowel dysfunction

The review found no eligible studies for this question.

1 finding from 1 review

Naloxone + oxycodone prolonged release tablets vs oxycodone

Symptoms of opioid withdrawal in the medium term · people with cancer irrespective of whether they were receiving palliative care opioid‐induced bowel dysfunction

Naloxone + oxycodone prolonged release tablets showed no clear difference in symptoms of opioid withdrawalfin the medium termb compared with oxycodone prolonged‐released tablets (low certainty).

1 finding from 1 review

Naloxone + oxycodone prolonged release tablets vs oxycodone

Serious adverse eventsg · people with cancer irrespective of whether they were receiving palliative care opioid‐induced bowel dysfunction

It is very uncertain whether naloxone + oxycodone prolonged release tablets changes serious adverse eventsg compared with oxycodone prolonged‐released tablets (very low certainty).

1 finding from 1 review

Naloxone + oxycodone prolonged release tablets vs oxycodone

Adverse events · people with cancer irrespective of whether they were receiving palliative care opioid‐induced bowel dysfunction

Naloxone + oxycodone prolonged release tablets showed no clear difference in adverse events compared with oxycodone prolonged‐released tablets (low certainty).

1 finding from 1 review