What do systematic reviews say?

Naldemedine vs placebo

Naldemedine showed no clear difference in serious adverse eventsh compared with placebo (low certainty).

• Mu‐opioid antagonists for opioid‐induced bowel dysfunction in people with cancer and people receiving palliative care 2022 · Cochrane Headline outcomes only
  RR 3.34 [0.85, 13.15]
  2 studies · 418 participants
  Low