Findings

What do systematic reviews say?

6 questions · 6 findings · 1 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 66.7%Low 2 · 33.3%Moderate 0 · 0%High 0 · 0%

NSAIDs vs combination (paracetamol and opioid) analgesic

Little or no pain at 1 to 3 days · people with acute soft tissue injury, such as ankle sprain

It is very uncertain whether NSAID changes little or no pain on day 7 or later compared with combination (paracetamol and opioid) analgesic (very low certainty).

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
RR 1.05 [0.88, 1.25]
2 studies · 138 participants
Very low

NSAIDs vs combination (paracetamol and opioid) analgesic

Swelling (7th day) · people with acute soft tissue injury, such as ankle sprain

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 230 participants
Very low

NSAIDs vs combination (paracetamol and opioid) analgesic

Return to function on day 7 or later Assessed as 'cure' · people with acute soft tissue injury, such as ankle sprain

It is very uncertain whether NSAID changes return to function on day 7 or later Assessed as 'cure' compared with combination (paracetamol and opioid) analgesic (very low certainty).

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
RR 1.28 [0.9, 1.81]
1 study · 89 participants
Very low

NSAIDs vs paracetamol

Pain intensity VAS (0 to 100; 0 = no pain, 100 = worst pain) · people with acute soft tissue injury, such as ankle sprain

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 467 participants
Low

NSAIDs vs paracetamol

Little or no swelling on day 7 or later · people with acute soft tissue injury, such as ankle sprain

NSAID showed no clear difference in little or no swelling on day 7 or later compared with paracetamol (low certainty).

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
RR 0.84 [0.58, 1.22]
1 study · 77 participants
Low

NSAIDs vs paracetamol

Return to function on day 7 or later (numbers returning to full function or returning to training) · people with acute soft tissue injury, such as ankle sprain

It is very uncertain whether NSAID changes return to function on day 7 or latere compared with paracetamol (very low certainty).

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
RR 0.99 [0.9, 1.09]
3 studies · 386 participants
Very low