Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 33.3%Low 1 · 33.3%Moderate 1 · 33.3%High 0 · 0%

NSAIDs vs opioid

Neurological adverse effects · acute soft tissue injury

NSAID probably leads to lower neurological adverse events compared with opioid (moderate certainty).

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
RR 0.4 [0.3, 0.53]
5 studies · 1151 participants
Moderate

NSAIDs vs combination (paracetamol and opioid) analgesic

Neurological adverse effects · people with acute soft tissue injury, such as ankle sprain

It is very uncertain whether NSAID changes neurological adverse events compared with combination (paracetamol and opioid) analgesic (very low certainty).

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
RR 0.52 [0.09, 2.84]
3 studies · 141 participants
Very low

NSAIDs vs paracetamol

Neurological adverse effects · people with acute soft tissue injury, such as ankle sprain

NSAID showed no clear difference in neurological adverse events compared with paracetamol (low certainty).

1 finding from 1 review

Oral non‐steroidal anti‐inflammatory drugs versus other oral analgesic agents for acute soft tissue injury 2020 · Cochrane Headline outcomes only
RR 0.85 [0.62, 1.17]
9 studies · 1679 participants
Low