Findings

What do systematic reviews say?

4 questions · 4 findings · 1 reviews · Drugs and Alcohol

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 50%Moderate 2 · 50%High 0 · 0%

Abstinence · cannabis dependence

N‐acetylcysteine showed no clear difference in participants abstinent at end of treatment compared with placebo (low certainty).

1 finding from 1 review

Pharmacotherapies for cannabis dependence 2019 · Cochrane Headline outcomes only
RR 0.89 [0.59, 1.35]
1 study · 302 participants
Low

Participants with at least some Side Effects · cannabis dependence

N‐acetylcysteine showed no clear difference in participants experiencing adverse effects compared with placebo (moderate certainty).

1 finding from 1 review

Pharmacotherapies for cannabis dependence 2019 · Cochrane Headline outcomes only
RR 0.94 [0.71, 1.23]
2 studies · 418 participants
Moderate

Withdrawals due to adverse events · cannabis dependence

N‐acetylcysteine showed no clear difference in participants withdrawn due to adverse effects compared with placebo (low certainty).

1 finding from 1 review

Pharmacotherapies for cannabis dependence 2019 · Cochrane Headline outcomes only
RR 3 [0.12, 72.15]
1 study · 116 participants
Low

Completion of scheduled treatment · cannabis dependence

N‐acetylcysteine showed no clear difference in completion of scheduled treatment compared with placebo (moderate certainty).

1 finding from 1 review

Pharmacotherapies for cannabis dependence 2019 · Cochrane Headline outcomes only
RR 1.06 [0.93, 1.21]
2 studies · 418 participants
Moderate