Findings

What do systematic reviews say?

4 questions · 4 findings · 3 reviews

No studies found 1 · 25%GRADE not reported 0 · 0%Very low 0 · 0%Low 2 · 50%Moderate 1 · 25%High 0 · 0%

Participants with at least some Side Effects · cannabis dependence

N‐acetylcysteine showed no clear difference in participants experiencing adverse effects compared with placebo (moderate certainty).

1 finding from 1 review

Pharmacotherapies for cannabis dependence 2019 · Cochrane Headline outcomes only
RR 0.94 [0.71, 1.23]
2 studies · 418 participants
Moderate

Withdrawals due to adverse events · cannabis dependence

N‐acetylcysteine showed no clear difference in participants withdrawn due to adverse effects compared with placebo (low certainty).

1 finding from 1 review

Pharmacotherapies for cannabis dependence 2019 · Cochrane Headline outcomes only
RR 3 [0.12, 72.15]
1 study · 116 participants
Low

Withdrawals due to adverse events · adults (aged 18 years+) with depression in bipolar disorder

The review found no eligible studies for this question.

1 finding from 1 review

Ketamine and other glutamate receptor modulators for depression in adults with bipolar disorder 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Adverse effects · sickle cell disease

N‐acetylcysteine (1200 mg) showed no clear difference in adverse effects compared with placebo (low certainty).

1 finding from 1 review

Antioxidant supplementation for sickle cell disease 2024 · Cochrane Headline outcomes only
RR 0.92 [0.75, 1.14]
1 study · 96 participants
Low