Findings

What do systematic reviews say?

5 questions · 5 findings · 1 reviews

No studies found 1 · 20%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 80%Moderate 0 · 0%High 0 · 0%

Adverse effects · adults and children with cystic fibrosis

1 finding from 1 review

Timing of dornase alfa inhalation for cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
25 participants
Low

FEV1 % predicted: absolute change from baseline · adults and children with cystic fibrosis

Morning showed no clear difference in FEV1 (% predicted) change from baseline compared with evening inhalation of dornase alfa (low certainty).

1 finding from 1 review

Timing of dornase alfa inhalation for cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
25 participants
Low

FVC (% predicted) Change from baseline · adults and children with cystic fibrosis

Morning showed no clear difference in FVC (% predicted) change from baseline compared with evening inhalation of dornase alfa (low certainty).

1 finding from 1 review

Timing of dornase alfa inhalation for cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
25 participants
Low

Measures of QoL and symptom scores · adults and children with cystic fibrosis

1 finding from 1 review

Timing of dornase alfa inhalation for cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
25 participants
Low

FEF25-75 · adults and children with cystic fibrosis

The review found no eligible studies for this question.

1 finding from 1 review

Timing of dornase alfa inhalation for cystic fibrosis 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found