Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

40 questions · 40 findings · 2 reviews

No studies found 9 · 22.5%GRADE not reported 0 · 0%Very low 4 · 10%Low 6 · 15%Moderate 20 · 50%High 1 · 2.5%

Methylxanthine vs placebo or control

Major neurodevelopmental disability in children aged 18 to 24 months CA · preterm infants at risk of or with apnea; preterm infants undergoing extubation

Methylxanthine probably leads to lower major neurodevelopmental disability at 18 to 24 months compared with placebo or control (moderate certainty).

1 finding from 1 review

Methylxanthine vs placebo or control

Positive‐pressure ventilation after institution of treatment · preterm infants at risk of or with apnea; preterm infants undergoing extubation

Methylxanthine may leads to lower positive‐pressure ventilation after institution of treatment compared with placebo or control (low certainty).

1 finding from 1 review