Findings

What do systematic reviews say?

3 questions · 3 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 3 · 100%Moderate 0 · 0%High 0 · 0%

Methylxanthine vs placebo or control

Positive‐pressure ventilation after institution of treatment · preterm infants at risk for apnea

Methylxanthine showed no clear difference in positive‐pressure ventilation after institution of treatment compared with placebo or control (low certainty).

1 finding from 1 review

Methylxanthine for the prevention and treatment of apnea in preterm infants 2023 · Cochrane Headline outcomes only
RR 1.33 [0.48, 3.72]
4 studies · 208 participants
Low

Methylxanthine vs placebo or control

Positive‐pressure ventilation after institution of treatment · preterm infants with apnea

Methylxanthine may leads to lower positive‐pressure ventilation after institution of treatment compared with placebo or control (low certainty).

1 finding from 1 review

Methylxanthine for the prevention and treatment of apnea in preterm infants 2023 · Cochrane Headline outcomes only
RR 0.34 [0.12, 0.97]
5 studies · 192 participants
Low

Methylxanthine vs placebo or control

Positive‐pressure ventilation after institution of treatment · preterm infants at risk of or with apnea; preterm infants undergoing extubation

Methylxanthine may leads to lower positive‐pressure ventilation after institution of treatment compared with placebo or control (low certainty).

1 finding from 1 review

Methylxanthine for the prevention and treatment of apnea in preterm infants 2023 · Cochrane Headline outcomes only
RR 0.61 [0.39, 0.96]
9 studies · 373 participants
Low