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What do systematic reviews say?

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Evidence found and GRADE certainty

24 questions · 24 findings · 1 reviews

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No studies found 11 · 45.8%GRADE not reported 0 · 0%Very low 1 · 4.2%Low 12 · 50%Moderate 0 · 0%High 0 · 0%

Methotrexate vs placebo

Treatment responsea · children and young people with JIA

Methotrexate may leads to higher treatment responsea(up to 6 months) compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Global well‐being: rated by participants · children and young people with JIA

Methotrexate showed no clear difference in participant global assessment of well‐being(up to 6 months) compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Serious adverse events(up to 6 months) · children and young people with JIA

Methotrexate showed no clear difference in serious adverse events(up to 6 months) compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Withdrawals due to adverse events · children and young people with JIA

Methotrexate showed no clear difference in withdrawals due to adverse events (up to 6 months) compared with placebo (low certainty).

1 finding from 1 review

Oral methotrexate plus intra‐articular glucocorticoid vs intra‐articular glucocorticoid alone

Sustained clinically inactive diseasec · children and young people with JIA

Oral methotrexate plus intra‐articular glucocorticoid showed no clear difference in sustained clinically inactive diseaseb(12 months) compared with intra‐articular glucocorticoid alone (low certainty).

1 finding from 1 review